Cardio-oncology & otherCohort study
Comprehensive Risk Factor Profiles, Coronary Heart Disease, and Life Expectancy in Cancer Survivors
- Cohort study
- matched noncancer controls
- UK Biobank
Authors' conclusion
The joint risk factor control is associated with a lower risk of CHD, MI, and CVD-related mortality among cancer survivors. Comprehensive assessment and optimization of modifiable risk factors may be clinically relevant for cardiovascular risk management in cardio-oncology survivorship care.
Study context
- Population
- Cancer survivors and matched noncancer controls from the UK Biobankcancer survivors, plus 58,228 matched noncancer controls · cancer survivors 14,557 · matched noncancer controls 58,228
- Participants
- 14,557 survivors
- Exposure
- Joint risk factor control across 9 domains (blood pressure, body mass index, low-density lipoprotein cholesterol, hemoglobin A1c, renal function, smoking, physical activity, diet, and sleep) and coronary heart disease (CHD), myocardial infarction (MI), cardiovascular disease (CVD) mortality and life expectancy
Main finding
As reported in the abstract
CHD, MI and CVD-related mortality per each additional controlled risk factor · median follow-up of 12.60 years
each additional controlled risk factorHazard ratio (95% CI)
CHD; adjusted for confounders
0.85(0.81–0.88)
MI; adjusted for confounders
0.81(0.74–0.88)
CVD-related mortality; adjusted for confounders
0.75(0.67–0.84)
Each additional controlled risk factor, as printed
Observational data: associations, not effects.
Further findings
Residual life expectancy at age 50
Events among cancer survivors · median follow-up of 12.60 years
- CHD events
- 1,298
- MI events
- 348
- CVD-related deaths
- 211
Original publication
Comprehensive Risk Factor Profiles, Coronary Heart Disease, and Life Expectancy in Cancer Survivors. JACC Adv. Published 17 July 2026. doi:10.1016/j.jacadv.2026.102968
Summarised from the published abstract; every number is checked against it