Coronary disease & ACSCohort study
Computed tomography derived segment involvement score and coronary artery calcium score when used in clinical routine— data from a Swedish Registry Cohort
- Swedish Registry Cohort
- 27 centres
Authors' conclusion
Both the extent of coronary atherosclerosis, measured by SIS, and the presence of obstructive disease are important predictors of outcomes. However, they do not provide additional prognostic value over CACS when used in routine clinical practice.
Study context
- Population
- Patients undergoing coronary computed tomography angiography (CCTA) for suspected coronary artery disease between 2006 and 2022patients followed for a median of 2.5 years
- Participants
- 23,034 patients
- Exposure
- prognostic value of segment involvement score (SIS) from coronary computed tomography angiography (CCTA) compared with coronary artery calcium score (CACS)
Main finding
As reported in the abstract
Adjusted risk of death, MI, and death or MI · median of 2.5 years
SIS ≥ 4 vs SIS = 0Hazard ratio (95% CI)
death
1.39(1.17–1.66)
MI
3.53(2.72–4.59)
death or MI
1.88(1.62–2.18)
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Death or MI (Area under the curve) | SIS Area under the curve 0.70 (95% CI 0.67–0.74) · CACS Area under the curve 0.68 (95% CI 0.65–0.72) |
| MI alone (Area under the curve) | SIS Area under the curve 0.72 (95% CI 0.67–0.77) · CACS Area under the curve 0.72 (95% CI 0.67–0.78) |
| Death (Area under the curve) | CACS Area under the curve 0.70 (95% CI 0.66–0.74) · SIS Area under the curve 0.67 (95% CI 0.63–0.70) |
- Death or myocardial infarction (MI) (Area under the curve): P = 0.08
- MI alone (Area under the curve): P = 0.69
- Death (Area under the curve): P = 0.008
Obstructive stenosis (≥50%)
- Independently associated with all outcomes but showed lower discrimination than SIS in receiver operating characteristic curve analyses
Original publication
Computed tomography derived segment involvement score and coronary artery calcium score when used in clinical routine— data from a Swedish Registry Cohort. Eur Heart J Cardiovasc Imaging. Published 13 April 2026. doi:10.1093/ehjci/jeag090
Summarised from the published abstract; every number is checked against it