Coronary disease & ACSCohort study
Contemporary Data on Sex Differences in Coronary Angiography Findings
- Population-based registry cohort study
- validation in the Western Denmark Heart Registry
Authors' conclusion
In 2 population-based cohorts undergoing first-time ICA for suspected NSTE-ACS, 40 to 50% of women had no significant CAD, approximately twice the proportion to men, highlighting ongoing challenges in risk stratification of patients referred for ICA.
Study context
- Population
- Adults without previously known coronary artery disease (CAD) undergoing first-time invasive coronary angiography (ICA) for suspected non-ST-elevation acute coronary syndrome (NSTE-ACS)patients included from Sweden and Western Denmark · Sweden (Swedish Coronary Angiography and Angioplasty Registry) 74,883 · Western Denmark (Western Denmark Heart Registry) 17,863
- Exposure
- Women compared to men
- Outcome
- Absence of significant CAD (normal angiography or <50% stenosis in all major epicardial vessels)
Main finding
As reported in the abstract
Women vs menAdjusted relative risk (95% CI)
Swedish Coronary Angiography and Angioplasty Registry: 40.9% vs 17.2%
2.59(2.51–2.67)
Western Denmark Heart Registry: 50.1% vs 25.2%
2.01(1.95–2.08)
Observational data: associations, not effects.
Secondary outcomes
No significant CAD in women below the age of 50 without any traditional cardiovascular risk factors (subgroup)
- Women below the age of 50 without any traditional cardiovascular risk factors with no significant CAD
- 74.8%
Original publication
Contemporary Data on Sex Differences in Coronary Angiography Findings. JACC Adv. doi:10.1016/j.jacadv.2026.102807
Summarised from the published abstract; every number is checked against it