Heart failure & cardiomyopathiesCohort study
Contemporary Decongestion Strategies in Patients Hospitalized for Heart Failure
- Retrospective cohort study
- US national EHR database
- 31 community-based health systems
Authors' conclusion
In a large-scale U.S. community-based cohort study of HF hospitalizations, estimated weight loss from inpatient decongestion remains highly variable, with weight gain observed across many admissions. Augmented diuresis strategies were infrequently used.
Study context
- Population
- Patients hospitalized for heart failure (HF), US, 2015–2022165,482 unique patients
- Participants
- 262,673 patients
- Outcome
- Inpatient weight change (primary indicator of decongestion)
Main finding
As reported in the abstract
Inpatient weight loss
Median inpatient weight loss, pounds (Q1-Q3: 0.0-12.8 pounds)
5.3
Median inpatient weight loss, kg (Q1-Q3: 0.0-5.8 kg)
2.4
Discharge weight higher than admission weight, % of encounters
20%
Observational data: associations, not effects.
Further findings
Serum creatinine increase ≥0.3 mg/dL from admission to inpatient peak
- Occurred in >30% of hospitalizations; associated with less weight loss
Adjunctive diuretic agents
- Used in <20% of encounters; associated with greater weight loss
Original publication
Contemporary Decongestion Strategies in Patients Hospitalized for Heart Failure. JACC Heart Fail. Published 7 April 2024. doi:10.1016/j.jchf.2024.04.002
Summarised from the published abstract; every number is checked against it