Heart failure & cardiomyopathiesCross-sectional study
Contemporary Implementation of Guideline-Directed Medical and Device Therapies in Heart Failure: Insights from the Central/Eastern Europe Quality of Care Centres Survey
- Prospective observational survey
- multicentre
- 21 centres in 12 Central/Eastern Europe (CEE) countries
Authors' conclusion
The CEE-QCC Survey highlights substantial in-hospital GDMT implementation and up-titration, though device use remains limited.
Study context
- Population
- Patients discharged after heart failure (HF) hospitalization in Central/Eastern Europe, March 2024–January 2025
- Participants
- 2,251 patients
- Outcome
- Implementation of GDMT and device use at discharge
- Follow-up
- Discharge
Main finding
As reported in the abstract
GDMT use, admission to discharge (total population)
- Angiotensin receptor-neprilysin inhibitor (ARNI) use, admission to discharge
- 17.1% to 34.3%
- Beta-blocker use, admission to discharge
- 69.4% to 92.4%
- Mineralocorticoid receptor antagonists (MRA) use, admission to discharge
- 44.0% to 82.1%
- SGLT2 inhibitor use, admission to discharge
- 30.8% to 79.9%
- Quadruple therapy at discharge
- 53.5%
- ≥50% target doses of titratable drugs achieved
- 18.8%
Observational data: associations, not effects.
Further findings
Guideline-directed medical therapies (GDMT) use, admission to discharge (HF with reduced ejection fraction (HFrEF))
- ARNI
- 26.3% to 55.1%
- Beta-blockers
- 69.8% to 95.3%
- MRA
- 49.5% to 89.0%
- SGLT2 inhibitors
- 36.2% to 79.8%
- Quadruple therapy at discharge
- 63.9%
- ≥50% target doses achieved
- 17.8%
- Lower ACEi use
- all p < 0.05
Device therapy in eligible HFrEF patients · discharge
- Discharged with, or referred for, ICD
- 21.3%
- CRT
- 17.4%
Predictors of GDMT underuse
- Older age, lower education, living alone, non-ischaemic HF, higher EF, CKD, hypotension, hyperkalaemia, prolonged hospitalization, residual oedema
Original publication
Contemporary Implementation of Guideline-Directed Medical and Device Therapies in Heart Failure: Insights from the Central/Eastern Europe Quality of Care Centres Survey. Eur J Heart Fail. Published 24 September 2025. doi:10.1002/ejhf.70031
Summarised from the published abstract; every number is checked against it