Continuation vs Withdrawal of Beta-Blockers and Outcomes After Myocardial Infarction With Preserved Left Ventricular Function
Main finding · Composite of recurrent AMI, myocardial revascularization, or all-cause mortalityResult — go to the resultAdjusted hazard ratio 1.09 95% CI 0.94–1.26Authors' conclusion
In patients with preserved left ventricular ejection fraction after AMI, discontinuation of BB within 180 days was not associated with a significantly increased risk of a composite outcome of death, recurrent AMI, or revascularization but was associated with increased risk of recurrent AMI and need for repeat revascularization.
Study context
- Population
- Patients who survived at least 180 days after acute myocardial infarction (AMI) from 2008 to 2017 with new beta-blocker (BB) prescription and left ventricular ejection fraction ≥50%included patients, 1,155 (24.2%) discontinued BB within 180 days of AMI discharge
- Participants
- 4,768 patients
- Exposure
- Early BB discontinuation and clinical outcomes
- Early BB discontinuationn = 1,155
- Outcome
- Composite of:
- Recurrent AMI
- Myocardial revascularization
- All-cause mortality
- Follow-up
- Within 5 years
Methodological detailslinked registry and administrative data
- Linked registry and administrative data
Main finding
As reported in the abstract
Adjusted hazard ratio
1.09
95% CI 0.94–1.26
Early BB discontinuation
adjusted HR 1.09 (95% CI 0.94–1.26)
- Patients who experienced the primary outcome
- 964 patients (20.2%)
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality
| Comparison | HR (95% CI) | |
|---|---|---|
| Early BB discontinuation | 1.04 (0.86–1.26) | |
| 0.512Hazard ratio (log scale) |
Recurrent AMI and repeat revascularization
- Early BB discontinuation associated with an increased risk for recurrent AMI and a higher rate of repeat revascularization
Original publication
Continuation vs Withdrawal of Beta-Blockers and Outcomes After Myocardial Infarction With Preserved Left Ventricular Function. JACC Adv. Published 22 May 2025. doi:10.
Summarised from the published abstract; every number is checked against it