Acute cardiac care & resuscitationCohort study
Continuum of Preshock to Classic Cardiogenic Shock in the Critical Care Cardiology Trials Network Registry
- Registry-based cohort study
- multicentre
- consecutive admissions
Authors' conclusion
In a large contemporary registry of cardiac critical illness, there exists a gradient of mortality for phenotypes along the preshock to CS continuum with risk for subsequent worsening of preshock states.
Study context
- Population
- Admissions to contemporary cardiac ICUs (CCCTN registry) along the preshock to cardiogenic shock (CS) continuumof 28,703 admissions, 47 sites
- Participants
- 2,498 admissions
- Exposure
- Preshock and early shock phenotypes vs SCAI stage C CS
- Outcome
- In-hospital mortality and incidence of subsequent hypoperfusion among pre- and early shock states
Main finding
As reported in the abstract
In-hospital mortality
- Overall in-hospital mortality
- 21.3% (95% CI: 19.7%-23.0%)
- Gradient across phenotypes, global P
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Subsequent hypoperfusion | Isolated low CO 42.3% · Isolated hypotension 30.9% |
| Distribution of phenotypes | Isolated low CO 4.8% · Isolated hypotension 4.4% · Normotensive CS 12.1% · SCAI stage C CS 78.7% |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Continuum of Preshock to Classic Cardiogenic Shock in the Critical Care Cardiology Trials Network Registry. JACC Heart Fail. Published 31 July 2024. doi:10.1016/j.jchf.2024.06.009
Summarised from the published abstract; every number is checked against it