Coronary Artery and Carotid Artery Plaques in Patients With Heterozygous Familial Hypercholesterolemia
Authors' conclusion
Coronary and carotid plaque scores were significantly correlated, and both were independently associated with MACEs.
Study context
- Population
- Patients with heterozygous familial hypercholesterolemia (FH) (heterozygous FH (HeFH)) at Kanazawa University Hospital with coronary CT and carotid ultrasound within 1 year
- Participants
- 622 patients
- Outcome
- Correlation of coronary and carotid plaque scores; association of plaque scores with MACE (CV death, unstable angina, MI or staged revascularization)
- Follow-up
- Median 13.2 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Correlation of coronary and carotid plaque scores, males (Spearman's r)
- 0.82; P < 0.001
- Correlation of coronary and carotid plaque scores, females (Spearman's r)
- 0.87; P < 0.001
- Major adverse cardiac events (MACEs) during median follow-up of 13.2 years
- 132
- Coronary plaque score and MACE, HR
- 3.33 (1.88-4.78); P < 0.001 (95% CI)
- Carotid plaque score and MACE, HR
- 2.24 (1.28-3.20); P < 0.001 (95% CI)
Observational data: associations, not effects.
Original publication
Coronary Artery and Carotid Artery Plaques in Patients With Heterozygous Familial Hypercholesterolemia. JACC Adv. Published 9 September 2023. doi:10.
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