Coronary disease & ACSMeta-analysis
Coronary Artery Bypass Graft Failure in Women
- Pooled analysis of individual patient data from randomised clinical trials
- systematic imaging follow-up
- mediation analysis
Authors' conclusion
Graft failure is more frequent in women and is associated with adverse cardiac events. The excess mortality risk associated with female sex among CABG patients is not mediated by graft failure.
Study context
- Population
- CABG patients in RCTs with systematic imaging follow-up
- Participants
- 4,413 patients · 7 RCTs
- Comparison
- Women vs men after CABG
- Womenn = 777
- Outcome
- Association of graft failure with MI and repeat revascularization between CABG and imaging
Pooled result
Graft failure and MI or repeat revascularization · median imaging follow-up 1.03 years
Odds ratio
3.94
95% CI 1.79–8.67
By group
Women
37.3%
Graft failure, patient level · Graft failure, graft level 20.5%
Men
32.9%
Graft failure, patient level · Graft failure, graft level 15.8%
Graft failure vs No graft failure
OR 3.94 (95% CI 1.79–8.67)
As reported in the abstract
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| Death after imaging, in women | OR 3.18 (95% CI 1.73–5.85) | |
| Death: female sex, mediation by graft failure — Women vs Men · direct effect | HR 1.84 (95% CI 1.35–2.50) | |
| Death: female sex, mediation by graft failure — Women vs Men · indirect effect via graft failure | HR 1.04 (95% CI 0.86–1.26) | |
| 0.20.5125Ratio (log scale) |
Original publication
Coronary Artery Bypass Graft Failure in Women. J Am Coll Cardiol. Published 9 July 2024. doi:10.1016/j.jacc.2024.04.046
Summarised from the published abstract; every number is checked against it