Coronary Artery Calcium for Risk Stratification Among Persons With Very High High-density Lipoprotein (HDL) Cholesterol
Main finding · All-cause mortalityResult — go to the resultHazard ratio 3.64 95% CI 1.21–11.01Authors' conclusion
Measurement of CAC may facilitate clinical risk assessment among individuals with very high HDL cholesterol.
Study context
- Population
- Persons with very high HDL cholesterol (≥77 mg/dL in men, ≥97 mg/dL in women), Cedars-Sinai Medical Center of the coronary artery calcium (CAC) Consortiumvalidation: 119 Multi-Ethnic Study of Atherosclerosis (MESA)
- Participants
- 446 persons
- Exposure
- Prevalent CAC vs no CAC
- Outcome
- All-cause mortality
- Follow-up
- Median 10.7 years
Methodological detailsexternal validation cohort (MESA)
- External validation cohort (MESA)
Main finding
As reported in the abstract
Hazard ratio
3.64
95% CI 1.21–11.01
Prevalent CACvs No CAC
HR 3.64 (95% CI 1.21–11.01)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortality (MESA validation sample)Individual traditional risk factors not associated | 2.39 (1.07–5.34) | |
| ASCVD (MESA validation sample) | 4.06 (1.11–14.84) | |
| 0.050.21520Hazard ratio (log scale) |
Prevalence of CAC
- Prevalent CAC
- 50%
- Median CAC score among those with CAC
- 118
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Coronary Artery Calcium for Risk Stratification Among Persons With Very High HDL Cholesterol. JACC Adv. Published 29 August 2024. doi:10.
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