Prevention & lipidsCross-sectional study
Coronary Artery Calcium Scores After Prophylactic Premenopausal Bilateral Salpingo-Oophorectomy
- Cross-sectional study
- nested in a nationwide cohort
- multivariable Poisson analyses
- external reference cohort
Authors' conclusion
Our results do not show a long-term adverse effect of surgical menopause on the development of CAC.
Study context
- Population
- Women at high familial risk of ovarian cancer; Coronary artery calcium (CAC) comparison in women aged 60–70 years328 aged 60–70 years
- Participants
- 733 women
- Exposure
- Premenopausal risk-reducing salpingo-oophorectomy (RRSO) vs postmenopausal RRSO
- Premenopausal RRSOn = 498
- Outcome
- Prevalence of any CAC (CAC >0), at least moderate CAC (CAC >100) and severe CAC (CAC >400)
Main finding
As reported in the abstract
Prevalence of CAC (any CAC >0, at least moderate CAC >100, severe CAC >400), women aged 60-70 years
Premenopausal RRSO vs Postmenopausal RRSORelative risk (95% CI)
any CAC (CAC >0)
0.93(0.75–1.15)
at least moderate CAC (CAC >100)
0.71(0.43–1.17)
severe CAC (CAC >400)
0.81(0.30–2.13)
Observational data: associations, not effects.
Further findings
CAC, premenopausal RRSO vs external reference cohort (n = 5,226)
- No difference in CAC vs similar aged reference cohort
CAC by timing of premenopausal RRSO (<41 vs 41-45 years)
- Timing of premenopausal RRSO did not affect the outcomes
Original publication
Coronary Artery Calcium Scores After Prophylactic Premenopausal Bilateral Salpingo-Oophorectomy. JACC CardioOncol. Published 19 November 2024. doi:10.1016/j.jaccao.2024.09.011
Summarised from the published abstract; every number is checked against it