Coronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes
Authors' conclusion
PRS-CAD's association with AMI varied by subtype but not by sex in young adults, warranting caution in application.
Study context
- Population
- Acute myocardial infarction (AMI) patients aged 18 to 55 years with a 2:1 female-to-male ratio from the VIRGO study, and controls from the MESA studyAMI patients (VIRGO) 2,079 · Controls (MESA) 3,761
- Participants
- 1,876 / 188 / 3,761
- Comparison
- PRS-CAD's association with AMI subtypes and with 1-year outcomes in AMI subtypes
- MI due to coronary artery diseasen = 1,876
- MI with nonobstructive coronary artery diseasen = 188
- Controls (MESA)n = 3,761
- Outcome
- Association of PRS-CAD with AMI subtype
Methodological detailsmultinomial logistic regression and Cox regression
- Multinomial logistic regression and Cox regression
Main finding
As reported in the abstract
Odds ratio, per 1-SD increase (95% CI)P value
MI due to coronary artery disease
1.82(1.67–1.97)
P < 0.001MI with nonobstructive coronary artery disease
1.13(0.96–1.34)
P = 0.14Per 1-SD increase, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (per 1-SD increase) (95% CI) | P value | |
|---|---|---|---|
| 1-year hospitalization or deathMI with nonobstructive coronary artery disease | 1.50 (1.08–2.10) | P = 0.02 | |
| 1-year hospitalization or deathMI due to coronary artery disease | 0.98 (0.91–1.07) | P = 0.67 | |
| 0.512Hazard ratio (log scale) |
PRS-CAD performance by sex
- PRS-CAD's performance did not differ by sex
Original publication
Coronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes. JACC Adv. Published 24 July 2025. doi:10.
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