Secondary analysis
Coronary Atherosclerotic Plaque Activity and Risk of Myocardial Infarction
- Secondary analysis of an international multicentre prospective study
Authors' conclusion
In patients with recent myocardial infarction and multivessel coronary artery disease, coronary atherosclerotic plaque activity prognosticates individual coronary arteries and patients at risk for myocardial infarction.
Study context
- Population
- Patients with recent MI and multivessel CAD2,094 coronary arteries
- Participants
- 691 patients
- Comparison
- Increased vs no increased coronary 18F-sodium fluoride uptake
- Increased plaque activityn = 679
- Primary endpoint
- Vessel-level MI
Primary result
As reported in the abstract
Hazard ratio
2.08
95% CI 1.16–3.72
P = 0.013
Events by treatment group
Increased plaque activity vs No increased plaque activity
HR 2.08 (95% CI 1.16–3.72); P = 0.013
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Vessel-level MI, by revascularization (subgroup) — Increased plaque activity vs No increased plaque activity · revascularized vessels | 1.02 (0.47–2.25) | ||
| Vessel-level MI, by revascularization (subgroup) — Increased plaque activity vs No increased plaque activity · untreated vessels | 3.86 (1.63–9.10) | ||
| Patient-level outcomes with increased plaque activity in multiple coronary arteries — Increased activity in multiple arteries vs No increased plaque activity · cardiac death or MI | 2.43 (1.37–4.30) | P = 0.002 | |
| Patient-level outcomes with increased plaque activity in multiple coronary arteries — Increased activity in multiple arteries vs No increased plaque activity · first MI | 2.19 (1.18–4.06) | P = 0.013 | |
| Patient-level outcomes with increased plaque activity in multiple coronary arteries — Increased activity in multiple arteries vs No increased plaque activity · total MIs | 2.50 (1.42–4.39) | P = 0.002 | |
| 0.10.31310Hazard ratio (log scale) |
- Vessel-level MI, by revascularization (subgroup): Pinteraction = 0.024
Original publication
Coronary Atherosclerotic Plaque Activity and Risk of Myocardial Infarction. J Am Coll Cardiol. Published 4 June 2024. doi:10.1016/j.jacc.2024.03.419
Summarised from the published abstract; every number is checked against it