Coronary disease & ACSSecondary analysis
Coronary Blood Flow in Women From the CENTURY Trial
- Post hoc analysis of the CENTURY randomised trial
- sex comparison
Authors' conclusion
In the randomized CENTURY trial, women had higher CBF than men across all comparable strata.
Study context
- Population
- Participants of the CENTURY trial with stable coronary artery disease (CAD), assessed by PET quantitative coronary blood flow
- Participants
- 331 vs 697
- Comparison
- Women vs men
- Womenn = 331
- Menn = 697reference
Primary result
As reported in the abstract
Rest and stress coronary blood flow (PET)
Rest and stress coronary blood flow (CBF) higher in women than in men across all comparable strata of age, BMI, risk factors and treatment
33%
Further findings
| Outcome | P value |
|---|---|
| Clinical outcomes (Kaplan-Meier) · through 14 years of follow-up — Women vs Men · all-cause death | log-rank P = 0.0223 |
| Clinical outcomes (Kaplan-Meier) · through 14 years of follow-up — Women vs Men · death or MI | log-rank P = 0.0138 |
| Clinical outcomes (Kaplan-Meier) · through 14 years of follow-up — Women vs Men · revascularization | log-rank P = 0.0004 |
| Clinical outcomes (Kaplan-Meier) · through 14 years of follow-up — Women vs Men · MACE | log-rank P < 0.0001 |
Clinical outcomes (Kaplan-Meier) · through 14 years of follow-up
- Women had approximately half the event rates of men
Baseline characteristics
- Similar age, BMI, hypertension, DM and cumulative summed risk scores
- Women had less established CAD, lower CAC and fewer PET perfusion defects
Estimated global endothelial shear stress (with published ~10% smaller coronary arteries in women)
- Potential global endothelial shear stress higher in women than in men
- ∼82%
- hypothetical; integrates published reports
Original publication
Coronary Blood Flow in Women From the CENTURY Trial. JACC Cardiovasc Imaging. Published 10 September 2026. doi:10.1016/j.jcmg.2026.07.017
Summarised from the published abstract; every number is checked against it