Prevention & lipidsRandomised controlled trial
Coronary computed tomography angiography to guide lipid management in an asymptomatic community-based population: RESPECT2 randomized controlled trial
- Randomised controlled trial
- pragmatic
- open-label
- assessor-blinded
Authors' conclusion
In asymptomatic populations, a CCTA-guided strategy modestly improved lipid management, though it increased invasive coronary procedures.
Study context
- Population
- Asymptomatic community-dwelling adults aged 40–69 years without cardiovascular disease (CVD) or prior lipid-lowering medication, Nanjing, China3,491 analysed
- Participants
- 3,503 adults
- Comparison
- Coronary computed tomography angiography (CCTA)-guided vs 10-year CVD risk-guided lipid management
- CCTAn = 1,748
- Usual-caren = 1,743reference
- Primary endpoint
- Proportion with regular lipid-lowering medication use (≥24 of preceding 30 days) at both follow-up visits
- Follow-up
- 6 and 12 months
Primary result
As reported in the abstract
Adjusted relative risk
1.57
95% CI 1.29–1.91
P < 0.001
Events by treatment group
CCTA vs Usual-care
adjusted RR 1.57 (95% CI 1.29–1.91); P < 0.001
Further findings
- Atherosclerotic CAD detected among those undergoing CCTA
- 37.3% · 565 of 1748
Safety
events
| Outcome | CCTA | Usual-care |
|---|---|---|
| Invasive coronary procedures · median follow-up 12.5 months | 29 | 1 |
Original publication
Coronary computed tomography angiography to guide lipid management in an asymptomatic community-based population: RESPECT2 randomized controlled trial. Eur J Prev Cardiol. Published 28 August 2026. doi:10.1093/eurjpc/zwag418
Summarised from the published abstract; every number is checked against it