Coronary disease & ACSCohort study
Coronary microvascular dysfunction and cardiovascular outcomes (Multicenter FLOW-CMD Registry): a prospective, multicentre cohort study in South Korea
- Prospective cohort study
- multicentre
- 7 tertiary hospitals in South Korea
- Enrolment April 22, 2022, to Nov 19, 2024
Authors' conclusion
In patients with suspected ischaemic heart disease undergoing invasive coronary angiography, coronary microvascular dysfunction coexisted with epicardial coronary artery disease and was associated with a higher risk of the composite of all-cause death, myocardial infarction, clinically driven repeat revascularisation, or hospitalisation for heart failure.
Study context
- Population
- Consecutive adults referred for clinically indicated invasive coronary angiography, South Korea5,764 screened
- Participants
- 1,003 adults
- Exposure
- Coronary microvascular dysfunction vs preserved microvascular function
- Outcome
- Composite of:
- All-cause death
- MI
- Clinically driven repeat revascularisation
- Hospitalisation for HF
- Follow-up
- Median 1.9 years
Main finding
As reported in the abstract
Hazard ratio
1.91
95% CI 1.22–2.99
P = 0.0047
Events by group
CMD vs Preserved microvascular function
HR 1.91 (95% CI 1.22–2.99); P = 0.0047
Observational data: associations, not effects.
Further findings
| Outcome | Obstructive epicardial coronary artery disease | Without obstructive epicardial coronary artery disease |
|---|---|---|
| Prevalence of coronary microvascular dysfunction, by obstructive epicardial CAD | 21.5% · 123 of 573 | 9.3% · 40 of 430 |
Original publication
Coronary microvascular dysfunction and cardiovascular outcomes (Multicenter FLOW-CMD Registry): a prospective, multicentre cohort study in South Korea. Lancet. Published 21 May 2026. doi:10.1016/s0140-6736(26)00666-5
Summarised from the published abstract; every number is checked against it