Coronary microvascular dysfunction and cardiovascular outcomes (Multicenter FLOW-CMD Registry): a prospective, multicentre cohort study in South Korea
Main findingResult — go to the resultHazard ratio 1.91 95% CI 1.22–2.99Authors' conclusion
In patients with suspected ischaemic heart disease undergoing invasive coronary angiography, coronary microvascular dysfunction coexisted with epicardial coronary artery disease and was associated with a higher risk of the composite of all-cause death, myocardial infarction, clinically driven repeat revascularisation, or hospitalisation for heart failure.
Study context
- Population
- Consecutive adults referred for clinically indicated invasive coronary angiography, South Korea5,764 screened
- Participants
- 1,003 adults
- Exposure
- Coronary microvascular dysfunction vs preserved microvascular function
- Outcome
- Composite of:
- All-cause death
- MI
- Clinically driven repeat revascularisation
- Hospitalisation for HF
- Follow-up
- Median 1.9 years
Methodological detailsmulticentre, 7 tertiary hospitals in South Korea, Enrolment April 22, 2022, to Nov 19, 2024
- Multicentre
- 7 tertiary hospitals in South Korea
- Enrolment April 22, 2022, to Nov 19, 2024
Main finding
As reported in the abstract
Hazard ratio
1.91
95% CI 1.22–2.99
P = 0.0047
Events by group
CMDvs Preserved microvascular function
HR 1.91 (95% CI 1.22–2.99); P = 0.0047
Observational data: associations, not effects.
Further findings
| Outcome | Obstructive epicardial coronary artery disease | Without obstructive epicardial coronary artery disease |
|---|---|---|
| Prevalence of coronary microvascular dysfunction, by obstructive epicardial CAD | 21.5% · 123 of 573 | 9.3% · 40 of 430 |
Original publication
Coronary microvascular dysfunction and cardiovascular outcomes (Multicenter FLOW-CMD Registry): a prospective, multicentre cohort study in South Korea. Lancet. Published 21 May 2026. doi:10.
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