Coronary disease & ACSResearch article
Coronary Microvascular Dysfunction in Ischemia With Nonobstructive Coronary Arteries and Associations With Sublingual Microvascular Abnormalities
- Adults with ischemia with nonobstructive coronary arteries (INOCA) underwent coronary function testing (CFT) for coronary microvascular dysfunction (CMD)
Authors' conclusion
Noninvasive SDF microscopy did not identify sublingual microvascular abnormalities in INOCA patients with CMD.
Study context
- Population
- Adults with ischemia with nonobstructive coronary arteries (INOCA) undergoing invasive coronary function testing (CFT)participants with INOCA who underwent CFT and sublingual sidestream darkfield (SDF) microscopy
- Participants
- 135 adults
- Comparison
- Sublingual SDF microscopy parameters by CMD status
- CMDn = 63
Main finding
As reported in the abstract
Sublingual PBR, %RBC and PMVD by CMD status
- No differences in sublingual perfused boundary region (PBR), %RBC, and perfused microvascular density (PMVD) were observed by CMD status
Further findings
Correlation of sublingual parameters with coronary flow reserve or index of microcirculatory resistance
- No correlations between sublingual parameters and continuous measures of coronary flow reserve or index of microcirculatory resistance were observed
Participant characteristics and sublingual parameters
- mean age
- 59.3 ± 12.1 years
- female
- 80%
- CMD present
- 63 participants (46.7%)
- median PBR
- 1.96 (IQR: 0.4)
- median %RBC
- 72.6 (IQR: 8.0)
- median PMVD
- 406 (IQR: 141)
Original publication
Coronary Microvascular Dysfunction in Ischemia With Nonobstructive Coronary Arteries and Associations With Sublingual Microvascular Abnormalities. JACC Adv. Published 5 August 2026. doi:10.1016/j.jacadv.2026.103097
Summarised from the published abstract; every number is checked against it