Coronary disease & ACSCohort study
Coronary Microvascular Dysfunction, Left Ventricular Remodeling, and Clinical Outcomes in Patients With Chronic Kidney Impairment
- Prospective cohort study
- single-centre
- blinded image analysis and event adjudication
- mediation analysis
Authors' conclusion
Coronary microvascular dysfunction, but not eGFR, was independently associated with abnormal cardiac mechanics and an increased risk of cardiovascular events.
Study context
- Population
- Patients undergoing cardiac stress PET, echocardiogram and renal function ascertainment, free of overt coronary, valvular and end-organ disease
- Participants
- 352 patients
- Exposure
- Associations of estimated glomerular filtration rate (eGFR) and coronary flow reserve (CFR) with cardiac mechanics and CV events
- Outcome
- Composite of death or hospitalization for MI or HF
Main finding
As reported in the abstract
eGFR and CFR associated with diastolic and systolic indices and future CV events
all P<0.05
Observational data: associations, not effects.
Further findings
Mediation of eGFR associations via CFR
- Associations between eGFR, cardiac mechanics and CV events partly mediated via CFR
Original publication
Coronary Microvascular Dysfunction, Left Ventricular Remodeling, and Clinical Outcomes in Patients With Chronic Kidney Impairment. Circulation. Published 29 November 2019. doi:10.1161/circulationaha.119.043916
Summarised from the published abstract; every number is checked against it