Coronary Microvascular Function in Asymptomatic Middle-Aged Individuals With Cardiometabolic Risk Factors
Authors' conclusion
In asymptomatic middle-aged individuals free of known cardiovascular disease, the presence of cardiometabolic risk factors and systemic (poly-vascular) subclinical atherosclerosis are associated with impaired coronary microvascular function. Better coronary microvascular function reduces atherosclerosis progression at follow-up.
Study context
- Population
- Asymptomatic middle-aged individuals free of known CVD (PESA)
- Participants
- 453 individuals
- Outcome
- Coronary microvascular function (rest and stress MBF, MPR by CMR) in relation to CV risk factors and subclinical atherosclerosis
Methodological detailsMedian age 52.6 years (range 48.9-55.8); 84.5% male
- Median age 52.6 years (range 48.9-55.8); 84.5% male
Main finding
As reported in the abstract
- Rest myocardial blood flow (MBF) directly associated with number of metabolic syndrome components, insulin resistance (HOMA-IR) and diabetes (age- and sex-adjusted)
- Myocardial perfusion reserve (MPR) reduced with several metabolic syndrome components, elevated HOMA-IR and diabetes
- Stress MBF inversely associated with CAC presence and global plaque burden
- Adjusted for age and sex
Observational data: associations, not effects.
Further findings
Atherosclerosis progression (increase in plaque volume) · 3 years
- Higher stress MBF and MPR associated with less atherosclerosis progression
Original publication
Coronary Microvascular Function in Asymptomatic Middle-Aged Individuals With Cardiometabolic Risk Factors. JACC Cardiovasc Imaging. Published 11 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it