Coronary disease & ACSMeta-analysis
Coronary Plaque Characteristics Associated With Major Adverse Cardiovascular Events in Atherosclerotic Patients and Lesions
- Systematic review and meta-analysis
Authors' conclusion
Characterization of CPCs identifies high-risk atherosclerotic plaques that place lesions and patients at risk for future MACE, albeit with modest sensitivity and positive predictive value
Study context
- Population
- Patients with coronary atherosclerosis; Coronary plaque characteristics (CPCs) assessed by intracoronary imaging (OCT, IVUS, NIRS-IVUS) or coronary CT angiography
- Participants
- 30,369 patients · 30 studies
- Comparison
- Lesions or patients with vs without high-risk coronary plaque characteristics (CPCs)
- Outcome
- Patient-level and lesion-level MACE
Pooled result
As reported in the abstract
Plaques with >1 CPC: highest accuracy for lesion-level MACE (AUC)
0.87
Further pooled results
Consistency across imaging modalities, clinical presentations and studies with prevailing hard outcomes
- Results mostly consistent
Original publication
Coronary Plaque Characteristics Associated With Major Adverse Cardiovascular Events in Atherosclerotic Patients and Lesions. JACC Cardiovasc Imaging. Published 4 October 2023. doi:10.1016/j.jcmg.2023.08.006
Summarised from the published abstract; every number is checked against it