Coronary Plaque Characteristics in Patients With Chronic Kidney Failure: Impact on Cardiovascular Events and Mortality
Authors' conclusion
In patients with chronic kidney failure, calcified and low-attenuation plaque burdens were independently associated with MACE and all-cause mortality, while high-risk plaques and coronary artery calcium score were only associated with MACE.
Study context
- Population
- Potential kidney transplant candidates with chronic kidney failure and few or no CAD symptoms undergoing coronary CT angiography as pre-transplant cardiac screening32% on dialysis
- Participants
- 484 candidates
- Exposure
- Coronary plaque characteristics on coronary CT angiography and association with MACE and all-cause mortality
- MACEn = 56
- Outcome
- MACE and all-cause mortality
- Follow-up
- Median 4.9 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Presence of high-risk plaqueMACE
2.0(1.0–3.7)
P = 0.040Higher coronary artery calcium scoreMACE
1.2(1.0–1.3)
P = 0.014Calcified plaque burden (per doubling)MACE
2.6(1.8–3.7)
P < 0.001Low-attenuation plaque burden (per doubling)MACE
2.6(1.5–4.5)
P = 0.001Calcified plaque burden (per doubling)all-cause mortality
1.6(1.2–2.1)
P = 0.002Low-attenuation plaque burden (per doubling)all-cause mortality
1.8(1.1–3.0)
P = 0.028Per doubling, as printed
- MACE
- 56 (12%)
- Died
- 69 (14%)
Observational data: associations, not effects.
Original publication
Coronary Plaque Characteristics in Patients With Chronic Kidney Failure: Impact on Cardiovascular Events and Mortality. Circ Cardiovasc Imaging. Published 30 September 2024. doi:10.
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