Coronary disease & ACSCohort study
Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease
- nonrandomized, real-world observational study
- registry
Authors' conclusion
In the REDUCER-I registry, patients with RA and AngioNOCAD had significant improvements in their symptoms and quality of life suggesting that CS Reducer implantation may be an effective therapy in these patients.
Study context
- Population
- Patients with refractory angina, objective evidence of ischemia on noninvasive stress testing, and no further revascularization options, who received a coronary sinus (CS) Reducer implantpatients who received a CS Reducer implant, 306 reported baseline coronary artery disease (CAD) type · AngioNOCAD 61 · obstructive CAD 245
- Participants
- 371 patients
- Exposure
- AngioNOCAD vs obstructive CAD after CS Reducer implantation
- AngioNOCADn = 61
- obstructive CADn = 245
Main finding
As reported in the abstract
≥1 Canadian Cardiovascular Society class improvement · Twelve months after CS Reducer implantation
P = 0.11
Observational data: associations, not effects.
Further findings
Baseline characteristics
age AngioNOCAD 65.8 ± 11.3 years · obstructive CAD 70.2 ± 8.7 years
prior coronary artery bypass grafting
prior percutaneous coronary intervention
Seattle Angina Questionnaires (SAQ) angina frequency, quality of life, and mean SAQ summary score · Twelve months
- both groups had significant improvements
- P < 0.01
Safety
MACE · Twelve-month · rates were similar
Original publication
Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease. JACC Adv. Published 20 March 2026. doi:10.1016/j.jacadv.2026.102686
Summarised from the published abstract; every number is checked against it