Coronary Venous Pressure and Microvascular Hemodynamics in Patients With Microvascular Angina: A Randomized Clinical Trial
An erratum to this article was published (JAMA Cardiol, 1 Oct 2023 ↗)
Authors' conclusion
Increased coronary venous pressure led to a reduction of microvascular resistances in patients with microvascular angina, a mechanism with potential implications for the therapy of this complex disease.
Study context
- Population
- Patients with moderate/severe angina (CCS class 2–4) due to microvascular dysfunction (IMR >25 mm Hg × s), without epicardial coronary diseasecrossover
- Participants
- 20 patients
- Comparison
- Coronary sinus (CS) balloon inflation vs sham
- Primary endpoint
- Hyperemic coronary resistance
Methodological detailsblinded, sham-controlled, crossover, single-centre
- Blinded
- Sham-controlled
- Crossover
- Single-centre
Primary result
As reported in the abstract
P < 0.001
Further findings
Hyperemic distal coronary pressure (Pd)
P = 0.01
Mean transit time
P = 0.008
Resting coronary resistance
P = 0.005
CS pressure increase vs sham
- Increase at rest
- 300%
- Increase during hyperemia
- 317%
- Both P < .001
Original publication
Coronary Venous Pressure and Microvascular Hemodynamics in Patients With Microvascular Angina: A Randomized Clinical Trial. JAMA Cardiol. Published 1 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →