Correlation Between Coronary Calcification and Cardiac Structure in Non-Dialysis Patients with Chronic Kidney Disease
Authors' conclusion
There is a correlation between CACS and cardiac structure and function in non-dialysis CKD patients, which may mainly involve abnormalities in left ventricular structure and cardiac diastolic function.
Study context
- Population
- Non-dialysis chronic kidney disease (CKD) patients who underwent CACS testing66.9% with coronary artery calcification (CAC)
- Participants
- 178 patients
- Exposure
- CACS categories: CACS = 0 vs 0 < CACS ≤ 100 vs CACS > 100
- Outcome
- Correlation between CACS and cardiac structure and function (cardiac ultrasound indexes)
Main finding
As reported in the abstract
Correlation of CACS with cardiac ultrasound indexes
- CACS positively correlated with LAD, LVDd, LVVd, SV and E/e
- P < 0.05
Observational data: associations, not effects.
Further findings
Predictors of severe CAC
- Heart valve calcification, heart failure (HF) diagnosis, LAD and LVDd essential in predicting severe CAC
Composite renal endpoint · mean follow-up 18.26 ± 10.17 months
- Composite renal endpoint event
- 65 (36.52%)
- Admitted to renal replacement therapy
- 36 (20.22%)
- Severe CAC: higher risk of renal function progression, CV and renal readmission, more pronounced HF symptoms
- P < 0.05
Original publication
Correlation Between Coronary Calcification and Cardiac Structure in Non-Dialysis Patients with Chronic Kidney Disease. ESC Heart Fail. Published 6 September 2024. doi:10.
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