Acute cardiac care & resuscitationResearch article
Cost-effectiveness of extracorporeal CPR for out-of-hospital cardiac arrest: a trial-based Markov model with a lifetime horizon
- trial-based Markov model with a lifetime horizon
- Probabilistic and deterministic sensitivity analyses
Authors' conclusion
Extracorporeal cardiopulmonary resuscitation for refractory OHCA has a low probability of being cost-effective. To enhance cost-effectiveness, improving ECPR effectiveness and reducing hospital costs of ECPR non-survivors are mandatory.
Study context
- Population
- Patients with refractory out-of-hospital cardiac arrest (OHCA) in the per-protocol population of a multicentre randomized controlled trial comparing extracorporeal cardiopulmonary resuscitation (ECPR) with CCPRECPR 33 · CCPR 47
- Participants
- 33 vs 47
- Comparison
- ECPR compared with conventional cardiopulmonary resuscitation (CCPR) for OHCA with a lifetime horizon
- ECPRn = 33
- CCPRn = 47
Main finding
As reported in the abstract
Mean ± SD costs · 1 year
ECPR
€26.372
mean · SD 28.237
CCPR
€10.356
mean · SD 37.706
Further findings
Survival · 1 year
Incremental costs, quality adjusted life years (QALYs) and incremental cost-effectiveness ratio (ICER) of ECPR · lifetime horizon
- mean incremental costs
- €160.969
- mean incremental QALYs
- 0.66
- ICER
- €242.122/QALY
Probability of ECPR being cost-effective
- At a willingness-to-pay threshold of €80.000 per QALY gained
- 46%
Drivers of the ICER
- The costs of non-survivors in both arms and the QALYs gained were the major drivers of the ICER
Original publication
Cost-effectiveness of extracorporeal CPR for out-of-hospital cardiac arrest: a trial-based Markov model with a lifetime horizon. Eur Heart J Acute Cardiovasc Care. Published 16 April 2026. doi:10.1093/ehjacc/zuag058
Summarised from the published abstract; every number is checked against it