Heart failure & cardiomyopathiesCohort study
Cost Offset With Quadruple Therapy for Heart Failure
- Economic evaluation
- registry-based
- Medicare-linked
- modelled treatment effects from pivotal randomized clinical trials (RCTs)
Authors' conclusion
Among US adults hospitalized with HFrEF, 1-year health care costs are substantial and driven predominantly by hospitalizations. Using combined trial effects and real-world Medicare data, this study found that implementation of quadruple GDMT would meaningfully reduce hospitalization-associated costs and often yield net savings after accounting for medication expenses.
Study context
- Population
- Adults ≥65 years hospitalized with heart failure with reduced ejection fraction (HFrEF), Get With The Guidelines-Heart Failure (GWTG-HF) registry linked to Medicare, 2016–2020
- Participants
- 50,598 adults
- Exposure
- Full quadruple guideline-directed medical therapy (GDMT) vs partial GDMT
- Outcome
- Mean per-patient total health care costs (Medicare Parts A and B) and net annual cost
- Follow-up
- 1 year after discharge
Main finding
As reported in the abstract
Hospitalization-associated expenditures and net annual cost · 1 year
Reduction in hospitalization-associated expenditures
$9780 per patient annually
95% CI $7900-$11 660
- Mean 1-year total health care costs per patient
- $41 802
- Costs attributable to all-cause hospitalizations per patient
- $25 172
- Annual drug costs
- $1223 to $16 136
- Net annual cost (most regimens yielding net savings)
- $8556 in savings to $6347 in net cost
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| HF hospitalizations · modelled | relative reduction 87% (95% CI 81%–91%) | |
| All-cause hospitalizations · modelled | reduction 61% (95% CI 51%–68%) | |
| −50050100Difference (linear scale) |
Original publication
Cost Offset With Quadruple Therapy for Heart Failure. JAMA Cardiol. Published 1 August 2026. doi:10.1001/jamacardio.2026.1552
Summarised from the published abstract; every number is checked against it