Creatinine-based European Kidney Function Consortium equation is superior to the Chronic Kidney Disease Epidemiology Collaboration equation for mortality risk stratification in general non-Black population
Authors' conclusion
Creatinine-based EKFC equation outperformed the CKD-EPI equation for the prediction of long-term all-cause and cardiovascular mortality in the general non-Black population.
Study context
- Population
- Non-Black adults aged ≥20 years without history of dialysis, NHANES 1999–2018median follow-up 112 months
- Participants
- 38,983 adults
- Exposure
- European Kidney Function Consortium (EKFC) vs CKD-EPI creatinine-based estimated glomerular filtration rate (eGFR) equation
- Outcome
- Prognostic value for all-cause and CV mortality
- Follow-up
- 10-year
Main finding
As reported in the abstract
- All-cause mortality
- integrated discrimination improvement 2.40%
- CV mortality
- integrated discrimination improvement 1.26%
- All-cause mortality
- net reclassification improvement 8.67%
- CV mortality
- net reclassification improvement 11.13%
Observational data: associations, not effects.
Further findings
Deaths during follow-up · median follow-up 112 months
- All-cause deaths
- 6103
- CV deaths
- 1558
- U-shaped relations between eGFR and risk of all-cause and CV mortality
Original publication
Creatinine-based European Kidney Function Consortium equation is superior to the Chronic Kidney Disease Epidemiology Collaboration equation for mortality risk stratification in general non-Black population. Eur J Prev Cardiol. Published 9 May 2023. doi:10.
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