Prevention & lipidsCross-sectional study
Cross-sectional and longitudinal associations of smoking behaviour with central arterial haemodynamic measures: the Framingham Heart Study
- Cross-sectional and longitudinal cohort study
- multivariable linear regression
Authors' conclusion
Central arterial measures are sensitive to differences and changes in smoking behaviour.
Study context
- Population
- Framingham Heart Study participants3,606 (55%) women
- Participants
- 6,597 participants
- Exposure
- Smoking behaviour groups vs never smoked
- Outcome
- Central arterial haemodynamic measures (augmentation index, characteristic impedance, central pulse pressure)
Main finding
As reported in the abstract
Augmentation index (AI), cross-sectional
Formerly quit vs Never smoked: P < 0.001 · Currently smoking vs Never smoked: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Never smoked | Formerly quit | Recently quit | Currently smoking | B (95% CI) | P value |
|---|---|---|---|---|---|---|
| AI by cigarettes per day (currently smoking) | 1.41 (0.47–2.34) | |||||
| AI and central pulse pressure by pack-years (quit smoking) — Higher pack-years vs Never smoked · AI | 0.85 (0.60–1.14) | |||||
| AI and central pulse pressure by pack-years (quit smoking) — Higher pack-years vs Never smoked · central pulse pressure | 0.84 (0.46–1.21) | |||||
| Increase in AI, longitudinal — Persistently quit vs Never smoked | 3.45 (SE 0.37) % | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract | P < 0.001 | |
| Increase in AI, longitudinal — Persistently smoked vs Never smoked | P = 0.002 |
- Increase in augmentation index (AI), longitudinal: Persistently quit 4.62 (SE 0.41) %
- Increase in AI, longitudinal: Persistently smoked 5.48 (SE 0.70) %
Central arterial measures by time since quit
- Negative linear association for AI; non-linear for characteristic impedance and central pulse pressure
- all P < 0.001
- Non-linear patterns with cessation by smoking burden (<20 vs. ≥20 pack-years)
Original publication
Cross-sectional and longitudinal associations of smoking behaviour with central arterial haemodynamic measures: the Framingham Heart Study. Eur J Prev Cardiol. Published 5 February 2025. doi:10.1093/eurjpc/zwaf012
Summarised from the published abstract; every number is checked against it