Computed Tomography (CT) Angiography, Healthy Lifestyle Behaviors, and Preventive Therapy: A Nested Substudy of the SCOT-HEART 2 Randomized Clinical Trial
Primary resultResult — go to the resultOdds ratio 3.42 95% CI 1.63–6.94Authors' conclusion
Results of this cohort study reveal that compared with cardiovascular risk scoring, coronary CT angiography was associated with modest improvements in healthier lifestyle behaviors, acceptance of recommended preventive therapy, and risk factor modification.
Study context
- Population
- Asymptomatic individuals aged 40 to 70 years without known CVD and with ≥1 CV risk factor, Scotland
- Participants
- 400 individuals
- Comparison
- Coronary CT angiography vs cardiovascular risk scoring
- Coronary CT angiographyn = 205
- Cardiovascular risk scoringn = 195reference
- Primary endpoint
- Composite compliance with NICE recommendations for diet, BMI, smoking and physical exercise
- Follow-up
- 6 months
Methodological detailsprimary care-based screening, Scotland, Conducted September 2020 to August 2024; enrolment September 2020 to January 2024
- Primary care-based screening
- Scotland
- Conducted September 2020 to August 2024; enrolment September 2020 to January 2024
Primary result
As reported in the abstract
Odds ratio
3.42
95% CI 1.63–6.94
P < 0.001
Events by treatment group
Coronary CT angiographyvs Cardiovascular risk scoring
OR 3.42 (95% CI 1.63–6.94); P < 0.001
Further findings
| Outcome | Cardiovascular risk scoring | OR (95% CI) | P value | |
|---|---|---|---|---|
| Use of lipid-lowering therapyCT angiographyvs Cardiovascular risk scoringSimilar use | 35% | 1.43 (0.96–2.15) | P = 0.08 | |
| 0.512Odds ratio (log scale) |
| Outcome | Cardiovascular risk scoring | P value |
|---|---|---|
| Recommended preventive therapyCT angiography vs Cardiovascular risk scoring | 75% | P < 0.001 |
| Acceptance of recommended therapyCT angiography vs Cardiovascular risk scoring | 46% | P < 0.001 |
| Use of antiplatelet therapyCT angiography vs Cardiovascular risk scoring | 0.5% | P < 0.001 |
- Recommended preventive therapy: CT angiography 51%
- Recommended preventive therapy: 105 of 205 vs 147 of 195
- Acceptance of recommended therapy: CT angiography 77%
- Acceptance of recommended therapy: 81 of 105 vs 68 of 147
- Use of lipid-lowering therapy: CT angiography 44%
- Use of lipid-lowering therapy: 90 of 205 vs 69 of 195
- Use of antiplatelet therapy: CT angiography 40%
- Use of antiplatelet therapy: 83 of 205 vs 1 of 195
Risk factors and 10-year CV risk
- Small incremental improvements with coronary CT angiography, largely driven by those with CT-defined coronary atheroma
Original publication
CT Angiography, Healthy Lifestyle Behaviors, and Preventive Therapy: A Nested Substudy of the SCOT-HEART 2 Randomized Clinical Trial. JAMA Cardiol. Published 1 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →