Heart failure & cardiomyopathiesDiagnostic or prognostic study
CT Coronary Angiography and Dynamic CT Myocardial Perfusion for Detection of Cardiac Allograft Vasculopathy
- Diagnostic accuracy study
Authors' conclusion
The combination of CT-MPI and CCTA demonstrated excellent diagnostic performance for the detection of CAV.
Study context
- Population
- Heart transplantation patients (median 4.3 years after transplantation)35 (55.6%) with cardiac allograft vasculopathy (CAV)
- Participants
- 63 patients
- Comparison
- Computed tomography-myocardial perfusion imaging (CT-MPI) and coronary computed tomography angiography (CCTA) vs invasive coronary angiography (ICA) with intravascular ultrasonography (IVUS) for CAV
- Outcome
- Diagnostic performance of dynamic CT-MPI and CCTA for CAV
Performance
As reported in the abstract
Detection of CAV
| Test or model | AUC | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|
| CCTA stenosis + MBFmin | 0.886 | 74.3% | 96.4% | 96.3% | 75.0% |
Further findings
| Outcome | Values | P value |
|---|---|---|
| MBFglobal, CAV vs no CAV | CAV median 128.7 mL/100 mL/min · No CAV median 150.4 mL/100 mL/min | P = 0.014 |
| MBFmin, CAV vs no CAV | CAV median 96.9 mL/100 mL/min · No CAV median 122.8 mL/100 mL/min | P < 0.001 |
Original publication
CT Coronary Angiography and Dynamic CT Myocardial Perfusion for Detection of Cardiac Allograft Vasculopathy. JACC Cardiovasc Imaging. Published 12 April 2023. doi:10.1016/j.jcmg.2022.12.031
Summarised from the published abstract; every number is checked against it