Cardio-oncology & otherCohort study
Culture-Negative Infective Endocarditis in the Modern Diagnostic Era
- Nationwide registry cohort study
- unselected cohort
Authors' conclusion
Using the first nationwide, unselected IE cohort, this study demonstrated a lower proportion of culture-negative cases than reported in previous studies. Patients with CNIE differed from CPIE in clinical presentation and disease characteristics, notably with less frequent fever and sepsis but higher embolic complication rates. However, culture-negative IE is highly heterogeneous and is better defined by distinct subgroups rather than by a single phenotype.
Study context
- Population
- All patients hospitalized with first-time left-sided infective endocarditis (IE), Danish NIDUS registry, 2016–2021
- Participants
- 2,875 patients
- Exposure
- Culture-negative IE vs culture-positive IE
- Culture-negative infective endocarditis (CNIE)n = 212
Main finding
As reported in the abstract
CNIE
7.4%
212 of 212
Observational data: associations, not effects.
Further findings
Medical history
Congenital heart disease
Previous cancer
Presentation at admission
Sepsis
Fever
Embolism
Valvular insufficiency
Prosthetic valve infection and valve surgery
Prosthetic valve infection
Valve surgery
PET-CT diagnostic yield
Vegetation size
- Positron emission tomography with computed tomography (PET-CT) diagnostic yield — PET-CT used in both groups
- 67%-68%
- PET-CT diagnostic yield — Diagnostic yield in prosthetic valve CNIE
- almost 50%
Prosthetic valve infection and valve surgery
- Similar in the two groups
Original publication
Summarised from the published abstract; every number is checked against it