Prevention & lipidsCohort study
Cumulative exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease
- Prospective cohort study
- longitudinal
- population-based
Authors' conclusion
Cumulative exposure to atherogenic lipid particles in young adulthood increases the risk for incident ASCVD later in life.
Study context
- Population
- Young adults aged 18 to <40 years, CARDIA cohort241 atherosclerotic cardiovascular disease (ASCVD) events
- Participants
- 4,366 adults
- Exposure
- Per 1 SD higher cumulative apolipoprotein B (apoB), low-density lipoprotein particle (LDL-P) and triglyceride-rich lipoprotein particle (TRL-P) exposure in young adulthood
- Outcome
- Incident ASCVD after age 40
- Follow-up
- Mean 19.3 years
Main finding
As reported in the abstract
Incident ASCVD after age 40, per 1 SD higher cumulative exposure
Hazard ratio (95% CI)
apoB (per 1 SD)
1.53(1.36–1.72)
LDL-P (per 1 SD)
1.54(1.36–1.75)
TRL-P (per 1 SD)
1.48(1.30–1.68)
Per 1 SD, as printed
- Adjusted HRs for each measure approximately
- 1.30
Observational data: associations, not effects.
Further findings
Usual apoB exposure threshold
- HR for ASCVD increased after usual apoB exposure of approximately
- 75 mg/dL/year
Original publication
Cumulative exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease. Eur Heart J. Published 4 July 2025. doi:10.1093/eurheartj/ehaf472
Summarised from the published abstract; every number is checked against it