Arrhythmias & electrophysiologyDiagnostic or prognostic study
Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation
- Prognostic cohort study
- two centres
Authors' conclusion
Integrating cellular Ca2+ handling signature with clinical predictors improves the prediction of post-operative AF, highlighting the potential of incorporating functional cellular data into clinical risk models.
Study context
- Population
- Patients undergoing cardiac surgery without pre-existing atrial fibrillation (AF)Ca2+ handling assessed in 94
- Participants
- 558 patients
- Comparison
- Clinical risk model with vs without cellular Ca2+-handling parameters
- Outcome
- Post-operative AF risk prediction (AUC)
Performance
As reported in the abstract
AUC (ROC) of post-operative AF risk prediction model with vs without Ca2+-handling parameters
Adding Ca2+-handling parameters increased AUC, training cohort
0.69 to 0.71
Adding Ca2+-handling parameters increased AUC, validation cohort
0.76 to 0.79
Further findings
Independent risk factors for post-operative AF
- Systolic Ca2+ level, age, left atrial dilatation, valvular heart disease, impaired renal function and serum magnesium identified as independent risk factors
Predictive score for AF at discharge and during rehabilitation
- AUC for AF at discharge
- 0.84
- AUC for AF during rehabilitation
- 0.71
- AUC for AF at discharge adding immediate post-operative AF as predictor
- 0.94
Single-cell Ca2+-handling clusters
- Clusters correlated with post-operative AF development and several cardiac diseases
Original publication
Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation. Eur Heart J. Published 9 September 2025. doi:10.1093/eurheartj/ehaf609
Summarised from the published abstract; every number is checked against it