Heart failure & cardiomyopathiesSecondary analysis
Decongestion and Outcomes in Patients Hospitalized for Acute Heart Failure
- Secondary analysis of the RELAX-AHF-2 randomised trial
Authors' conclusion
Among patients with AHF who were still hospitalized at day 5, residual congestion was common and independently associated with worse outcome.
Study context
- Population
- Patients hospitalized for acute heart failure (AHF) still in hospital at day 5, RELAX-AHF-2 trial
- Participants
- 5,900 patients
- Comparison
- Residual congestion at day 5 vs no residual congestion
- Composite congestion score (CCS) ≥1n = 3,380
- CCS ≥3n = 1,066
- Primary endpoint
- CV death or rehospitalization for HF or renal failure
- Follow-up
- 180 days
Primary result
As reported in the abstract
Each group vs no residual congestionAdjusted hazard ratio (95% CI)P value
CCS ≥1
1.32(1.15–1.51)
P < 0.001CCS ≥3
1.62(1.39–1.88)
P < 0.001Further findings
| Outcome | CCS ≥1 | CCS ≥3 | No residual congestion |
|---|---|---|---|
| Prevalence of residual congestion at day 5 | 57.3% | 18.1% | Not reported in the abstract |
Original publication
Decongestion and Outcomes in Patients Hospitalized for Acute Heart Failure. JACC Heart Fail. Published 27 November 2024. doi:10.1016/j.jchf.2024.09.013
Summarised from the published abstract; every number is checked against it