Decreased free fatty acid levels associated with adverse clinical outcomes in coronary artery disease patients with type 2 diabetes: findings from the PRACTICE study
Authors' conclusion
A non-linear U-shaped association was identified between baseline FFA levels and mortality or ischaemic events in CAD patients with T2DM.
Study context
- Population
- Coronary artery disease (CAD) patients in China (PRACTICE study), December 2016 to October 2021
- Participants
- 10,395 patients
- Exposure
- Baseline free fatty acid (FFA) concentration categories
- Outcome
- Mortality (all-cause mortality and cardiac mortality)
- Follow-up
- Median 24 months
Main finding
As reported in the abstract
Mortality vs baseline FFA level
All-cause deaths, total cohort
222
Cardiac deaths, total cohort
164
Non-linear U-shaped association between FFA and mortality risk (adjusted); lowest risk at
310 µmol/L
Observational data: associations, not effects.
Secondary outcomes
Ischaemic events (MACE or MACCE) vs baseline FFA level · median follow-up 24 months
- MACE, total cohort
- 718
- MACCE, total cohort
- 803
- Non-linear U-shaped relationship; lowest risk at
- 500 µmol/L
Mortality or ischaemic events, by T2DM status (subgroup)
- U-shaped relationship observed only in T2DM, not in non-diabetic CAD patients
Original publication
Decreased free fatty acid levels associated with adverse clinical outcomes in coronary artery disease patients with type 2 diabetes: findings from the PRACTICE study. Eur J Prev Cardiol. Published 13 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →