Cardio-oncology & otherResearch article
Deep Inspiration Breath Hold in Left-Sided Breast Radiotherapy
- Cost-effectiveness analysis (microsimulation and discrete event simulation modelling study)
- dosimetric planning comparison
- state-transition microsimulation model (SCORE2)
- time-driven activity-based costing
- provider perspective
- willingness-to-pay threshold €40,000
Authors' conclusion
Despite time investments, DIBH is cost-effective in the Belgian population.
Study context
- Population
- Patients with left-sided breast cancer receiving radiotherapy (Belgian population)plans with both techniques
- Participants
- 100 patients
- Comparison
- Deep inspiration breath hold (DIBH) vs free breathing (FB)
- Outcome
- Cost-effectiveness of DIBH vs FB (incremental cost-effectiveness ratio per QALY)
- Follow-up
- 20 years
Main finding
As reported in the abstract
Cost-effectiveness (ICER)
- DIBH
- incremental cost 617 € per left-sided breast cancer patient (95% CI €615-€619)
- DIBH
- incremental quality-adjusted life-years (QALYs) 0.04 QALYs per patient (95% CI 0.05–0.05)
- ICER (willingness-to-pay threshold €40,000)
- €14,023 per QALY
Further findings
| Outcome | Estimate | |
|---|---|---|
| Total CV events · 20 years · base case scenario | absolute risk reduction 1.72% (95% CI 1.67%–1.76%) | |
| Fatal CV events · 20 years · base case scenario | absolute risk reduction 0.69% (95% CI 0.67%–0.72%) | |
| Maximum achievable throughput (reduction with DIBH) · DIBH increased treatment times | reduction 12.48% (95% CI 12.36%–12.75%) | |
| −1001020Difference (linear scale) |
Original publication
Deep Inspiration Breath Hold in Left-Sided Breast Radiotherapy. JACC CardioOncol. Published 2 July 2024. doi:10.1016/j.jaccao.2024.04.009
Summarised from the published abstract; every number is checked against it