Heart failure & cardiomyopathies
Deep Learning-Derived Cardiac Chamber Volumes and Mass From PET/Computed Tomography (CT) Attenuation Scans: Associations With Myocardial Flow Reserve and Heart Failure
Authors' conclusion
Deep learning-derived chamber volumes and left ventricular mass from CT attenuation correction were predictive of heart failure hospitalization and reduced myocardial flow reserve in patients undergoing cardiac PET perfusion imaging. This anatomic data can be routinely reported along with other PET/CT parameters to improve risk prediction.
Study context
- Population
- Patients with cardiac PET/CTpatients with cardiac PET/CT from 6 sites
- Participants
- 18,079 patients
- Comparison
- Deep learning-derived CT chamber volumes and left ventricular mass in association with heart failure hospitalization and reduced myocardial flow reserve
- Outcome
- Heart failure hospitalization
- Follow-up
- Median 4.3 years
Methodological details6 sites
- 6 sites
Main finding
As reported in the abstract
Patients who experienced heart failure hospitalization
1721
9.5%
Patients with 3 or 4 abnormal chamber volumes vs patients with normal volumes: likelihood of heart failure hospitalization
7×
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Heart failure hospitalization, per chamber measureLeft atrial volume · adjusted · In adjusted analyses | 1.25 (1.19–1.30) | |
| Heart failure hospitalization, per chamber measureRight atrial volume · adjusted · In adjusted analyses | 1.29 (1.23–1.35) | |
| Heart failure hospitalization, per chamber measureRight ventricular volume · adjusted · In adjusted analyses | 1.25 (1.20–1.31) | |
| Heart failure hospitalization, per chamber measureLeft ventricular volume · adjusted · In adjusted analyses | 1.27 (1.23–1.35) | |
| Heart failure hospitalization, per chamber measureLeft ventricular mass · adjusted · In adjusted analyses | 1.25 (1.18–1.32) | |
| 0.512Hazard ratio (log scale) |
Reduced myocardial flow reserve
| Odds ratio (95% CI) | ||
|---|---|---|
| Left atrial volumeMultivariable · In multivariable analyses | 1.14 (1.0–1.19) | |
| Ventricular massIn multivariable analyses | 1.12 (1.6–1.17) | |
| 0.512Odds ratio (log scale) |
- Reduced myocardial flow reserve: multivariable; CI as printed (lower bound 1.6 exceeds estimate)
Original publication
Deep Learning-Derived Cardiac Chamber Volumes and Mass From PET/CT Attenuation Scans: Associations With Myocardial Flow Reserve and Heart Failure. Circ Cardiovasc Imaging. Published 13 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →