Valvular & structural heart diseaseSecondary analysis
Defining an Optimal Result of Transcatheter Tricuspid Valve Intervention: Results From the Tri-QOL Study
- Secondary analysis of the Tri-QOL study (pooled patient-level data)
- observational
- 6 single-arm studies
- multivariable models
Authors' conclusion
Health status improvement after TTVI was most strongly associated with the degree of TR reduction, although there was minimal additional improvement for most patients beyond a 3-grade reduction in TR.
Study context
- Population
- Patients with ≥severe tricuspid regurgitation (TR) who underwent transcatheter tricuspid valve interventions (TTVI)
- Participants
- 1,056 patients · 6 single-arm studies
- Comparison
- Association of baseline and 1-month TR grade with change in KCCQ-OS after TTVI
- Primary endpoint
- Change in KCCQ-OS by TR grade at baseline, TR grade at 1 month and their interaction
- Follow-up
- 1 month
Primary result
As reported in the abstract
Change in KCCQ-OS vs TR reduction
Mean change in KCCQ-OS
17.0±21.3 points
Further findings
TR grade at 1 month
- None/trace
- 21.7%
- Mild
- 27.2%
- Moderate
- 28.1%
- ≥Severe
- 23.1%
Original publication
Defining an Optimal Result of Transcatheter Tricuspid Valve Intervention: Results From the Tri-QOL Study. Circulation. Published 2 February 2026. doi:10.1161/circulationaha.125.076542
Summarised from the published abstract; every number is checked against it