Acute cardiac care & resuscitationSecondary analysis
Delay From First Symptoms in Patients Presenting With STEMI and Cardiogenic Shock: Insights From the DanGer Shock Trial
- secondary analysis of the international, multicenter, randomized, open-labeled DanGer Shock trial
Authors' conclusion
In patients with ST-segment-elevation myocardial infarction complicated with cardiogenic shock, treatment with an mAFP was associated with reduced all-cause mortality, but the treatment benefit appeared to weaken with prolonged time from the onset of symptoms to randomization.
Study context
- Population
- Patients with ST-segment-elevation myocardial infarction and cardiogenic shock, stratified into quartiles according to delay from first symptoms to randomizationof 355 patients enrolled in this substudy
- Participants
- 345 patients
- Comparison
- Microaxial flow pump (mAFP) vs standard care alone
Primary result
As reported in the abstract
Mortality across quartiles of time from onset of symptoms to randomization · 180 days
- log-rank P
- P = 0.002
Further findings
| Outcome | Values | odds ratio (95% CI) | |
|---|---|---|---|
| Death from any cause, mAFP vs standard care, by delay · 180 days — mAFP vs standard care alone · 3 lowest quartiles combined | 0.51 (0.31–0.84) | ||
| Death from any cause, mAFP vs standard care, by delay · 180 days — mAFP vs standard care alone · highest quartile | 0.92 (0.38–2.22) | ||
| 0.20.5125Odds ratio (log scale) |
| Outcome | Values | Estimate |
|---|---|---|
| Baseline characteristics across delay quartiles | earliest quartile Median age 66 years (interquartile range, 57-73) · Women 15% · latest quartile Median age 71 years (interquartile range, 62-79) · Women 34% |
- Baseline characteristics across delay quartiles — Age trend P
- P =0.005
- Death from any cause, mAFP vs standard care, by delay: P for interaction = 0.26
Original publication
Delay From First Symptoms in Patients Presenting With STEMI and Cardiogenic Shock: Insights From the DanGer Shock Trial. Circ Cardiovasc Interv. Published 12 January 2026. doi:10.1161/circinterventions.125.015718
Summarised from the published abstract; every number is checked against it