Arrhythmias & electrophysiology
Delayed Pericardial Effusion Following Ethanol Infusion of the Vein of Marshall
Main finding · Delayed PE (newly detected PE >10 mm occurring ≥7 days after ablation and resulting in rehospitalization)Overlap-weighted HR 3.18 95% CI 1.15–8.74- Registry analysis
- propensity score overlap weighting
+1 more
- propensity score overlap weighting
Authors' conclusion
EIVOM is associated with an increased risk of delayed PE, characterized by late onset, systemic inflammation, frequent need for invasive management, and high recurrence risk. These findings support the need for extended echocardiographic monitoring beyond the standard postprocedural period.
Study context
- Population
- Patients with persistent atrial fibrillation (AF) from the China-AF RegistryEthanol infusion of the vein of Marshall (EIVOM) group 8,151 · non-EIVOM group 6,950
- Participants
- 15,101 patients
- Exposure
- EIVOM group vs non-EIVOM group
- EIVOM groupn = 8,151
- non-EIVOM groupn = 6,950
- Outcome
- Delayed PE (newly detected PE >10 mm occurring ≥7 days after ablation and resulting in rehospitalization)
Main finding
As reported in the abstract
Delayed PE (newly detected PE >10 mm occurring ≥7 days after ablation and resulting in rehospitalization)
Overlap-weighted HR
3.18
95% CI 1.15–8.74
P = 0.025
By group
EIVOM group vs non-EIVOM group
overlap-weighted HR 3.18 (95% CI 1.15–8.74); P = 0.025
- Delayed pericardial effusion (PE) in total cohort
- 0.17%
Observational data: associations, not effects.
Further findings
Time to manifestation of delayed PE
| Outcome | EIVOM group | non-EIVOM group | |
|---|---|---|---|
| Recurrence post-discharge, among patients with EIVOM-related delayed PE · requiring prolonged management | 20% | Not reported in the abstract | non-EIVOM group: not reported in the abstract |
- Invasive intervention required, among EIVOM group patients with delayed PE
- 85% · 17 of 20 of 8,151
Time to manifestation of delayed PE
- median 38 days in EIVOM group vs 14 days in non-EIVOM group
Original publication
Delayed Pericardial Effusion Following Ethanol Infusion of the Vein of Marshall. JACC Clin Electrophysiol. Published 4 August 2026. doi:10.1016/j.jacep.2026.06.048
Summarised from the published abstract; every number is checked against it