Heart failure & cardiomyopathiesCross-sectional study
Demographic-Based Personalized Left Ventricular Hypertrophy Thresholds for Hypertrophic Cardiomyopathy Diagnosis
- Cross-sectional study
- multicentre
Authors' conclusion
Using a fixed LVH threshold ≥15 mm biases LVH ascertainment in both population and HCM cohorts. A demographic-adjusted approach for LVH improves ascertainment and diagnostic accuracy.
Study context
- Population
- Healthy adults (Reference Cohort), a population cohort with comorbidities, and an hypertrophic cardiomyopathy (HCM) cohort from 6 international centres; Maximum wall thickness (MWT) by cardiovascular magnetic resonance (CMR) with a validated AI algorithm3 cohorts
- Exposure
- Demographic-adjusted left ventricular hypertrophy (LVH) thresholds vs fixed ≥15-mm MWT threshold
Main finding
As reported in the abstract
Population Cohort classified hypertrophic, traditional ≥15-mm threshold
4.3% (n = 1,854); 89% male
Population Cohort classified hypertrophic, demographic-adjusted thresholds
2.2% (n = 945); 56% male
HCM Cohort with MWT <15 mm, traditional threshold
27% of female, 18% of male
HCM Cohort below threshold, demographic-adjusted thresholds
7% of female, 15% of male (P < 0.0001)
Observational data: associations, not effects.
Further findings
MWT in HCM Cohort, female vs male
MWT z-score Female 5.1 · Male 4.5
- MWT in HCM Cohort, female vs male: absolute MWT P < 0.001
- MWT in HCM Cohort, female vs male: z-score P = 0.05
HCM Cohort sex ratio
- Male-to-female ratio
- 2:1
Original publication
Summarised from the published abstract; every number is checked against it