Cardiometabolic & kidneyCohort study
Denture use and risk for cardiometabolic disease: observational and Mendelian randomization analyses
- Observational cohort and Mendelian randomisation study
- Linkage disequilibrium score (LDSC) regression
- Mendelian randomization
Authors' conclusion
Our study supported potential causal associations between the genetic liability for denture use and risks for HF, AS, T2D, and related clinical risk factors.
Study context
- Population
- UK Biobank participantsUK Biobank
- Participants
- 495,938 participants
- Exposure
- Denture use vs no denture use
- Outcome
- CMDs: CAD, MI, heart failure (HF), any stroke, ischaemic stroke, haemorrhagic stroke, T2DM and related clinical risk factors
Main finding
As reported in the abstract
Genetic liability for denture use (Mendelian randomization)
Each group vs no denture useOdds ratio (CI)
Denture useHF
1.49(1.20–1.83)
Denture useT2DM
1.11(1.01–1.24)
Denture use/DMFSany stroke; genetically determined denture use/DMFS
1.21(1.04–1.40)
Observational data: associations, not effects.
Further findings
Observational analysis, various cardiometabolic diseases (CMDs)
- Denture use associated with higher risks of various CMDs
- 14-25%
Genetic correlation (LDSC) with CMDs
- Positive genetic correlation, rg
- 0.21-0.38
Cardiometabolic risk factors
- Genetically predicted denture use/DMFS significantly associated with HDL cholesterol, TG, waist circumference, waist-to-hip ratio and height
Original publication
Denture use and risk for cardiometabolic disease: observational and Mendelian randomization analyses. Eur J Prev Cardiol. Published 11 September 2023. doi:10.1093/eurjpc/zwad295
Summarised from the published abstract; every number is checked against it