Heart failure & cardiomyopathies
Depressive Symptoms and 6-Year KCCQ Health Status in Chronic Heart Failure: Findings From the Cognition.Matters-HF Cohort
Authors' conclusion
In ambulatory chronic HF, average KCCQ-based health status remained stable over 6 years despite substantial individual variation. Depressive symptoms were strongly associated with concurrent health status, but recent worsening did not predict subsequent KCCQ deterioration or adverse clinical events.
Study context
- Population
- Patients with ambulatory chronic heart failure (HF)patients with HF assessed at baseline and 6, 12, 36, and 69 months
- Participants
- 148 patients
- Exposure
- Between-person and within-person PHQ-9 depressive symptom components and Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OSS) health status
- Outcome
- KCCQ-OSS trajectory
- Follow-up
- 69 months
Main finding
As reported in the abstract
KCCQ-OSS
78.0-76.6
Change
−1.4; 95% CI: −4.6 to 1.8
P for time = 0.065
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Concurrent KCCQ-OSS by between-person PHQ-9 burdenAssociated with lower concurrent KCCQ-OSS | β −3.44 per point (95% CI −4.00 to −2.88) | P < 0.001 |
| Concurrent KCCQ-OSS by within-person PHQ-9 worseningAssociated with lower concurrent KCCQ-OSS | β −1.80 (95% CI −2.50 to −1.11) | P < 0.001 |
Recent PHQ-9 worsening and subsequent KCCQ-OSS, ≥5-point KCCQ decline, or all-cause death/HF hospitalization
- Recent PHQ-9 worsening did not predict subsequent KCCQ-OSS, a ≥5-point KCCQ decline, or all-cause death/HF hospitalization
- Exploratory lagged analyses
Correlates of KCCQ-OSS
- NYHA functional class and 6-min walking distance, but not N-terminal pro-B-type natriuretic peptide, left ventricular ejection fraction, or executive function, were independently associated with KCCQ-OSS
Original publication
Depressive Symptoms and 6-Year KCCQ Health Status in Chronic Heart Failure: Findings From the Cognition.Matters-HF Cohort. JACC Adv. Published 30 October 2026. doi:10.
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