Derivation and Validation of ESC-0/1-h Algorithm for High-Sensitivity Troponin T and I in Cancer Patients
Authors' conclusion
Cancer-optimized ESC 0/1-h hs-cTnT/I algorithm cutoffs increased efficacy maintaining high safety.
Study context
- Population
- Patients with active or past cancer presenting to the emergency department with suspected non-ST-elevation myocardial infarctionhs-cTnT eligible cancer patients 541 · hs-cTnI-Architect eligible patients 516 · internal validation cohort 130 · external validation cohort 195
- Comparison
- Cancer-optimized European Society of Cardiology (ESC) 0/1-h hs-cTnT/I cutoffs vs the current cutoffs
- Outcome
- Efficacy, hs-cTnT algorithm
Methodological detailsderivation and external validation in 2 independent cohorts, central adjudication by 2 independent cardiologists
- Derivation and external validation in 2 independent cohorts
- Central adjudication by 2 independent cardiologists
Performance
As reported in the abstract
P < 0.001
Further findings
| Outcome | Cancer-optimized ESC 0/1-h cutoffs | Current cutoffs | P value |
|---|---|---|---|
| Efficacy, hs-cTnI-Architect algorithmEfficacy increased | 78.9% (95% CI 75.2–82.2) | 59.3% (95% CI 55.0–63.5) | P < 0.001 |
- Efficacy, hs-cTnI-Architect algorithm: 516 eligible patients
Efficacy, hs-cTnI-Architect algorithm
- Sensitivity and specificity again remained high and comparable
Validation
- Findings were confirmed in internal and external validation cohorts
- n = 130 and n = 195 patients, respectively
Original publication
Derivation and Validation of ESC-0/1-h Algorithm for High-Sensitivity Troponin T and I in Cancer Patients. JACC Adv. Published 22 May 2025. doi:10.
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