Arrhythmias & electrophysiology
Design and rationale of a multicenter randomized trial assessing strategies for catheter ablation of persistent atrial fibrillation- The STAR atrial fibrillation (AF) 3 trial
Study context
- Population
- Patients with persistent AF of more than 3 months duration referred for a first catheter ablation procedurepatients recruited, enrollment completed
- Participants
- 617 patients
- Planned comparison
- Compare the strategy of pulmonary vein isolation (PVI) alone with two strategies that add ablation to PVI: PVI+drivers ablation and PVI+posterior wall isolation
- Primary endpoint
- Time to first recurrence of documented atrial tachyarrhythmia (atrial fibrillation, atrial flutter, or atrial tachycardia) lasting 30 s or longer; a repeat left atrial ablation procedure at any time also qualifies
- Follow-up
- Between 91 days and 18 months after a single ablation procedure
Methodological detailsrandomized, enrollment at 33 centers in Europe, Canada, Australia, USA and Japan, equal randomization to three ablation strategies, 18-month follow-up, design and rationale report
- Randomized
- Enrollment at 33 centers in Europe, Canada, Australia, USA and Japan
- Equal randomization to three ablation strategies
- 18-month follow-up
- Design and rationale report
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Design and rationale of a multicenter randomized trial assessing strategies for catheter ablation of persistent atrial fibrillation- The STAR AF 3 trial. Am Heart J. Published 22 October 2026. doi:10.
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