Cardio-oncology & otherTrial design
Design and rationale of RECOVER-AUTONOMIC: A randomized platform trial evaluating interventions for Long COVID postural orthostatic tachycardia syndrome
- multicenter, randomized, double-blinded, placebo-controlled, platform trial
- flexible, adaptive design
- factorial design
Study context
- Population
- Adults with Long COVID and postural orthostatic tachycardia syndrome (POTS)
- Planned comparison
- Intravenous immunoglobulin (IVIG) or ivabradine with matching placebo, and (in a factorial design) coordinated nonpharmacologic care or usual care
- Primary endpoint
- Change in orthostatic intolerance symptoms measured by the Orthostatic Hypotension Questionnaire/Orthostatic Intolerance Questionnaire
- Follow-up
- From baseline to the end of intervention
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Design and rationale of RECOVER-AUTONOMIC: A randomized platform trial evaluating interventions for Long COVID postural orthostatic tachycardia syndrome. Am Heart J. Published 18 February 2026. doi:10.1016/j.ahj.2026.107384
Summarised from the published abstract; every number is checked against it