Heart failure & cardiomyopathiesTrial design
Design and rationale of the Urine Sodium-directed Diuretic Adjustment Strategy in Heart Failure (US-DASH) trial
- Pragmatic, single-center, randomized, controlled, open-label
- stratification by eGFR (greater than versus less than 60 mL/min/1.73 m²) and number of home diuretics (0-1 versus 2+)
Study context
- Population
- Patients with acute heart failure
- Planned comparison
- a high-threshold natriuresis target improves natriuresis compared with both a low-threshold natriuretic strategy and traditional methods
- Primary endpoint
- 24-hour natriuresis
- Follow-up
- 24-hour
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Design and rationale of the Urine Sodium-directed Diuretic Adjustment Strategy in Heart Failure (US-DASH) trial. Am Heart J. Published 6 October 2026. doi:10.1016/j.ahj.2026.107622
Summarised from the published abstract; every number is checked against it