Cardiometabolic & kidney

Design, rationale, and baseline characteristics of the dapagliflozin in haemodialysis (Dapagliflozin in Hemodialysis (DAPA-HD)) trial

ESC Heart FailPublished academic, multicentre, randomized, double-blind, placebo-controlled trial

Study context

Population
Patients with kidney failure receiving haemodialysisplanned enrolment
Participants
220 patients
Planned comparison
Dapagliflozin vs placebo
Primary endpoint
Change in left ventricular mass indexed to body surface area using echocardiography
Follow-up
After 6 months of treatment
Methodological detailsStratified block randomization was based on patient-reported residual urine volume
  • Stratified block randomization was based on patient-reported residual urine volume

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Design, rationale, and baseline characteristics of the dapagliflozin in haemodialysis (DAPA-HD) trial. ESC Heart Fail. Published 9 April 2026. doi:10.1093/eschf/xvag104

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