Acute cardiac care & resuscitation
Design and rationale of the TANGO2 trial: A randomized controlled non-inferiority trial of bystander compression-only cardiopulmonary resuscitation (CPR) versus standard CPR in out-of-hospital cardiac arrest
Study context
- Population
- Adults with out-of-hospital cardiac arrest of presumed medical etiology, dispatch-assisted bystander CPR; all Emergency Medical Dispatch Centers in Sweden and selected sites in Italyestimated enrollment, per-protocol EMS-treated out-of-hospital cardiac arrest (OHCA) patients, trial enrolling
- Participants
- 3,260 adults
- Planned comparison
- Bystander Compression-only CPR (CO-CPR) vs standard CPR
- Primary endpoint
- 30-day survival
- Follow-up
- 30 days
Methodological details1:1 randomization by dispatchers via an integrated decision-support system, per-protocol analysis prespecified as primary, supported by modified intention-to-treat analysis, non-inferiority defined as an absolute risk difference above −1.0 percentage points
- 1:1 randomization by dispatchers via an integrated decision-support system
- Per-protocol analysis prespecified as primary, supported by modified intention-to-treat analysis
- Non-inferiority defined as an absolute risk difference above −1.0 percentage points
No results yet. This paper sets out the design of a trial; its results are to come.
Further findings
Study conduct
- Start date
- 2017
- Estimated completion date
- December 2027
- Current status: Enrolling
Original publication
Design and rationale of the TANGO2 trial: A randomized controlled non-inferiority trial of bystander compression-only CPR versus standard CPR in out-of-hospital cardiac arrest. Am Heart J. Published 6 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it